Demographic and Clinical Characteristics of Severe Asthma Patients Worldwide

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Other
• Non-interventional study design, other:
  Historical study describing the baseline data of a cohort of severe asthma patients

Study drug and medical condition

• Medical condition to be studied:
  Asthma

Population studied

• Short description of the study population:
  Severe asthma patients aged 18 years or older who received treatment according to GINA step 5 ot uncontrolled at Step 4. Uncontrolled is defined as having severe asthma symptoms or frequent exacerbations.
• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Special population of interest:
  Other
• Special population of interest, other:
  Asthma patients
• Estimated number of subjects:
  4990

Study design details

• Main study objective:
  The primary objective of this study is to describe the global severe asthma population using aggregate demographic and clinical measures such as healthcare resource utilisation, blood test measurements, comorbidities, etc.The secondary objective is to descriptively compare the distribution of demographic and clinical attributes of severe asthma patients across sub-populations (regions/countries)
• Outcomes:
  Demographic and clinical characteristics of the global severe asthma population, Descriptive comparison of baseline and clinical characteristics of severe asthma population across countries
• Data analysis plan:
  Descriptive statistics will be computed for all demographics and clinical variables for the patient population as categorical variables, and count and percentage of non-missing observations will be reported for each category.Country or region (group) comparison will be examined with contingency tables. Frequencies and 95% confidence intervals will be shown for each characteristic and group difference will be tested for statistical significance via chi-square test for comparison of counts. Statistical significance will be defined as p <0.05.

Documents

Study results

ISAR global report 2017_final_updated_24.01.2019_ENCePP