Asthma management in France and the United Kingdom

Study type

• Study topic:
  Disease /health condition
• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

  Other
• If ‘other’, further details on the scope of the study:
  Asthma management comparison
• Data collection methods:
  Secondary use of data

Non-interventional study

• Non-interventional study design:
  Other
• Non-interventional study design, other:
  Historical observational, cohort study

Study drug and medical condition

• Medical condition to be studied:
  Asthma

Population studied

• Short description of the study population:
  French patients: aged 6 to 40 years with at least 3 dispensations of respiratory drug (R03 ATC code except R03DX05, R03AC18, R03BB04, R03BB01, R03AK03 and R03AK04) in 2007/2013 at 3 different dates will qualify to enter the cohort. The date of entry in the cohort will be the date of the 3rd dispensation (entry date).; UK patients: aged 6 to 40 years with a diagnosis of asthma recorded in the database in 2007/2013. Patients older than 40 will be described as well in a complementary analysis, but they will not be compared to French patients.
• Age groups:
  Adolescents (12 to < 18 years)

  Adults (18 to < 46 years)
• Special population of interest:
  Other
• Special population of interest, other:
  Asthma patients
• Estimated number of subjects:
  35000

Study design details

• Main study objective:
  To compare asthma management between patients in the United Kingdom and in France, in particular with regards to at-risk treatment patterns.
• Outcomes:
  Describe asthma managements with regards to the following:1. LABA with no ICS prescription (Monotherapy)2. Ratio units dispensed of LABA/ICS >= 2 (unit= canisters or prescriptions in the UK)3. High use of SABAs (>= 12 canisters dispensed/prescribed)
• Data analysis plan:
  Asthma managements will be described with regards to the following:1. LABA with no ICS prescription (Monotherapy)2. Ratio units dispensed of LABA/ICS >= 2 (unit= canisters or prescriptions in the UK)3. High use of SABAs (>= 12 canisters dispensed/prescribed)Comparisons will be made:1. Within country: This will compare asthma management in 2007/2008 vs 2013/20142. Between countries: Differences in management between countriesTreatment groups will be compared using t-test / Mann Whitney U-test (depending on distribution) for variables measured on the interval/ratio scale and using a chi square test for categorical variables.