Asthma and Type 2 Comorbidities - Real-life Characterisation of Patients with Active Asthma and Type 2 Asthma Comorbidities

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

  Cross-sectional

Study drug and medical condition

• Medical condition to be studied:
  Asthma

Population studied

• Age groups:
  Term newborn infants (0 – 27 days)

  Infants and toddlers (28 days – 23 months)

  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)

  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  400000

Study design details

• Main study objective:
  To estimate the frequency of each combination of T2 co-morbidities in a real world active asthma population, and to select a limited set of common co-morbidity patterns for further investigation.To describe the overlap between these patterns and between individual co-morbidities within the patterns in terms of patient demography, and asthma severity, resource utilisation and costs.
• Data analysis plan:
  Co-occurrence patterns of the co-morbidities will be visualised in frequency tables, and associations between co-morbidities measured using likelihood ratios. Associations of patterns with patient characteristics and health care resource utilisation and costs will be done using multivariable regression. Principal components analysis will be used to identify clustering of inter-related co-morbidities.