Study type

Study topic

Human medicinal product

Study type

Non-interventional study

Scope of the study

Assessment of risk minimisation measure implementation or effectiveness

Data collection methods

Secondary data collection
Non-interventional study

Non-interventional study design

Systematic review and meta-analysis
Study drug and medical condition

Anatomical Therapeutic Chemical (ATC) code

(C09DX01) valsartan, amlodipine and hydrochlorothiazide
(C09BX03) ramipril, amlodipine and hydrochlorothiazide
(C09DX03) olmesartan medoxomil, amlodipine and hydrochlorothiazide
(C03AX01) hydrochlorothiazide, combinations
(C03EA01) hydrochlorothiazide and potassium-sparing agents
(C03AB03) hydrochlorothiazide and potassium
(C03AA03) hydrochlorothiazide
(C09XA54) aliskiren, amlodipine and hydrochlorothiazide
(C09XA52) aliskiren and hydrochlorothiazide
Population studied

Short description of the study population

The study focused on association between hydrochlorothiazide/anti-hypertensive drugs and non-melanoma skin cancer/malignant melanoma identified from the existing available evidence.

Age groups

Adults (18 to < 46 years)
Adults (46 to < 65 years)
Adults (65 to < 75 years)
Adults (75 to < 85 years)
Adults (85 years and over)

Estimated number of subjects

50000
Study design details

Main study objective

This report aims to provide a review of existing available evidence regarding the association between HCTZ/ anti-hypertensive drugs and NMSC/MM, together with a quality appraisal of the existing studies.

Outcomes

malignant melanoma, non-melanoma skin cancer

Data analysis plan

To describe the type of studies, their characteristics and the variables used for confounding adjustment by them.
Documents
Study publications
Morales DR, Pacurariu A, Slattery J, Kurz X. Association between hydrochlorothi…