Is low dose aspirin associated with a reduced risk of overall cancer among the French population (ASPIK)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Effectiveness study (incl. comparative)

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Anatomical Therapeutic Chemical (ATC) code:
  (B01AC06) acetylsalicylic acid

  acetylsalicylic acid
• Medical condition to be studied:
  Neoplasm malignant

Population studied

• Age groups:
  • Adult and elderly population (≥18 years)

    • Adults (18 to < 65 years)

      • Adults (46 to < 65 years)
    • Elderly (≥ 65 years)

      • Adults (65 to < 75 years)
      • Adults (75 to < 85 years)
      • Adults (85 years and over)
• Estimated number of subjects:
  111000

Study design details

• Main study objective:
  This study aims to assess the effect of low dose aspirin use on overall cancer incidence among the French population.
• Outcomes:
  overall cancer (excluding non melanoma skin cancer), specific cancer sites
• Data analysis plan:
  We estimated the effect of low dose aspirin on cancer incidence by using a dynamic model to account for the competing risk of death in the presence of time-dependent exposure and risk factors.