Longitudinal Analyses of Blood Pressure and Risk of Alzheimer´s disease and Vascular Dementia in 2.6 million people over 2 decades (BP and Dementia)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Hypertension

  Blood pressure decreased

  Dementia Alzheimer's type

  Vascular dementia

Population studied

• Age groups:
  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  2600000

Study design details

• Main study objective:
  The primary objectives of the analysis is to estimate the age-specific association between systolic blood pressure (SBP) and diastolic blood pressure (DBP) and future risk of Alzheimer´disease, vascular dementia and all dementia
• Outcomes:
  Alzheimer´s disease,Vascular dementia,All dementia, Stroke,All-cause death
• Data analysis plan:
  To relate blood pressure (BP) to risk of dementia, Poisson regression models will be used to estimate incidence rates and rate ratios. Adjustment for age (in 5-year bands), sex, and baseline date (at index). To update age at risk as people move through the age categories. Adjustment of rate ratios for additional baseline cardiovascular covariates. To fit separate Poisson regression models in each category for follow intervals and age-at-risk. Correction for regression dilution bias using serial BP measurements. To assess selective mortality bias, a simulation study to investigate the size of competing risk of mortality, with ´joint frailty´ models. To confirm well-established association of BP with stroke and all mortality

Documents

Study, other information

BP vas and AD__ICPE 2017_LSHTM & OXON