Study type

Study topic

Human medicinal product

Study type

Non-interventional study

Scope of the study

Drug utilisation

Data collection methods

Secondary use of data
Non-interventional study

Non-interventional study design

Cohort
Study drug and medical condition

Anatomical Therapeutic Chemical (ATC) code

(M01AB05) diclofenac
diclofenac
(M01AC06) meloxicam
meloxicam
(M01AE01) ibuprofen
ibuprofen
(M01AE02) naproxen
naproxen
(M01AE03) ketoprofen
ketoprofen
(M01AH01) celecoxib
celecoxib
(M01AH05) etoricoxib
etoricoxib
Population studied

Short description of the study population

Adult patients receiving the prescription for the selected NSAIDS which includes dicofenac, meloxicam, ibuprofen, naproxen, ketoptofen, celecoxib and etoricoxib from October 1, 2012, to September 30, 2013, in the MarketScan databases and from April 1, 2013, to March 31, 2014, in the CPRD.

Age groups

  • Adult and elderly population (≥18 years)
    • Adults (18 to < 65 years)
      • Adults (18 to < 46 years)
      • Adults (46 to < 65 years)
    • Elderly (≥ 65 years)
      • Adults (65 to < 75 years)
      • Adults (75 to < 85 years)
      • Adults (85 years and over)

Estimated number of subjects

300000
Study design details

Main study objective

To accomplish the following: Describe demographic characteristics, specific comorbidities, selected comedications, and selected potential indications for use among patients treated with selected systemic NSAIDs (including diclofenac),Describe treatment patterns, including dose, duration of treatment, and switching patterns, among patients treated with selected systemic NSAIDs(including diclofenac)

Outcomes

Patient characterization and prescription patterns

Data analysis plan

All study measures will be analyzed descriptively through the tabular and graphical display of mean values, medians, ranges, and standard deviations for continuous variables of interest and proportions for categorical variables (with corresponding 95% confidence intervals, as appropriate).