Burden of disease in patients with COPD and high blood eosinophil counts (High eosinophils and COPD)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Chronic obstructive pulmonary disease

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  40000

Study design details

• Main study objective:
  To study the role of high blood eosinophil counts in the burden and costs of COPD in a broad real-life population of patients in the UK
• Outcomes:
  COPD exacerbation rate for objective 1, COPD-related short-term rehospitalisation for objective 2, COPD-related HRU and costs for objectives 3&4,
• Data analysis plan:
  Binomial regression will be performed to estimate the adjusted association between high BEC and COPD exacerbations for objective 1.Cox-regression will be performed to estimate the adjusted association between high BEC and rehospitalisation for objective 2.HRU and mean costs will be described for different subgroups of patients on triple therapy who are at risk of exacerbations for objective 3.A one- or two-step generalized linear model with gamma distribution and log link will be used to perform regression analysis with total costs as the outcome variable for objective 4.