Treatment Patterns of newly initiated oral anticoagulants on Japanese non-vascular atrial fibrillation patients using a Japanese claims database

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

  Drug utilisation

Study drug and medical condition

• Name of medicine:
  ELIQUIS

  XARELTO
• Name of medicine, other:
  warfarin, Prazaxa
• Medical condition to be studied:
  Atrial fibrillation

Population studied

• Age groups:
  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  480000

Study design details

• Main study objective:
  The main objective to evaluate the number of non-valvular atrial fibrillation patients newly treated with oral anticoagulants between the period of March 2011 to June 2016 and type/dose of oral anti-coagulants these patients have received.
• Outcomes:
  Type and dose of newly prescribed anti-coagulant to AF patients, Patient baseline characteristics including past medical history, demographics and concurrent drug treatment
• Data analysis plan:
  Descriptive statistics of each oral anti-coagulant for baseline characteristics and treatment status on index date defined as the date of first prescription of anti-coagulant. Exploratory analysis to use propensity score matching method to see if treatment groups can be matched using various co-variates such as clinical history, gender, age, previous and concomittant medication, year and month of index date, time from AF diagnosis, type and dose of oral anti-coagulant.