Burden of severe uncontrolled eosinophilic asthma in the UK population

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Disease epidemiology

Non-interventional study

• Non-interventional study design:
  Cohort

Study drug and medical condition

• Medical condition to be studied:
  Asthma

Population studied

• Age groups:
  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)

  Adults (18 to < 46 years)

  Adults (46 to < 65 years)

  Adults (65 to < 75 years)

  Adults (75 to < 85 years)

  Adults (85 years and over)
• Estimated number of subjects:
  200000

Study design details

• Main study objective:
  The main objective is to describe the size of the population of patients with severe uncontrolled eosinophilic asthma and their burden of disease and health care resource utilisation
• Outcomes:
  Asthma exacerbations and Healthcare Resource Utilisation, Indirect costs of asthma exacerbations
• Data analysis plan:
  A historical follow-up study will be performed among the UK population of patients with active asthma extracted from OPCRD and CPRD at the last recorded blood eosinophil count (index date).The distribution of asthma severity and control, treatment status, blood eosinophilia, other asthma determinants and their combinations will be described in the baseline year prior to the index date in the total population and stratified by four age groups and the presence of blood eosinophilia using three cut-off values. The rate of exacerbations and HRU will be described in the outcome year in patients with severe uncontrolled eosinophilic asthma, defined as patients with blood eosinophilia, treated with high dose ICS + LABA who had ≥2 exacerbations in the baseline year. All analyses are performed in patients with and without an overlapping diagnosis of COPD separately.