Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects: Results from the National Health Survey for Children and Adolescents (KiGGS) (ADDUCE)

Study type

• Study type:
  Non-interventional study
• Scope of the study:
  Assessment of risk minimisation measure implementation or effectiveness

Non-interventional study

• Non-interventional study design:
  Cross-sectional

Study drug and medical condition

• Study drug International non-proprietary name (INN) or common name:
  METHYLPHENIDATE HYDROCHLORIDE
• Medical condition to be studied:
  Attention deficit hyperactivity disorder

  Cardiovascular disorder

  Partial seizures

Population studied

• Age groups:
  Children (2 to < 12 years)

  Adolescents (12 to < 18 years)
• Estimated number of subjects:
  12373

Study design details

• Main study objective:
  To examine the potential association between the use of methylphenidate and adverse outcomes using data from the KIGGs dataset.
• Outcomes:
  Blood pressure: systolic and diastolic blood pressure, Pulse, growth, seizures
• Data analysis plan:
  The multiple propensity score method will be used, multiple PS is estimated using multinomial logistic regression analysis. To estimate the treatment effects while controlling for initial differences, the multiple PS, which are calculated for each treatment category, are included as extra predictors in the regression analysis.