Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT)

Study identification

• EU PAS number:
  EUPAS19636
• Study ID:
  50407
• Official title and acronym:
  Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT)
• DARWIN EU® study:
  No
• Study countries:
  United States
• Study description:
  Large healthcare database research informs both clinical and payment decisions as well as improves the quality and affordability of healthcare for public health. Interest and capacity to use data contained in large healthcare databases has increased exponentially, however, much of the evidence from those valuable large healthcare databases suffers from lack of reproducibility, transparency and scientific robustness. This project aims to evaluate the current state of reproducibility of large published healthcare database studies. We will achieve this objective by taking a systematic random sample of healthcare database studies published in a leading clinical or epidemiology journal within the last 5 years and attempting to reproduce them based on the reported methods in publications and appendices. We plan to sample studies that were conducted using different large healthcare data sources.
• Study status:
  Planned

Study timelines

Date when funding contract was signed

Planned:01/08/2017

Study start date

Planned:01/08/2017

Data analysis start date

Planned:01/08/2018

Date of final study report

Planned:01/01/2021

Sources of funding

Non-for-profit organisation (e.g. charity)

Other

More details on funding

Laura and John Arnold Foundation, Brigham and Women's Hospital

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable