The study will investigate the incidence of adverse events in a real world setting in migraine patients with long-term exposure to fremanezumab relative to migraine patients treated with other preventive migraine pharmacotherapy targeting the CGRP pathway or other preventive migraine pharmacotherapy not targeting the CGRP pathway. The objective of the study are to evaluate the long-term safety of fremanezumab in all patients with migraine through evaluation of incidence of all adverse events, and to evaluate the safety of fremanezumab in a sub population of CV compromised patients. The secondary objective is to examine the long-term safety of fremanezumab in patients with migraine by migraine treatment duration. This is a long-term, prospective, comparative, non-interventional, observational, controlled study. Patients aged 18 years or older with migraine who have been newly prescribed fremanezumab, non fremanezumab CGRP-pathway targeting preventive migraine medications or non-CGRP-pathway targeting preventive migraine medications will be identified and followed for a minimum of 3 years. Study variables include exposure to the study medications, incidence of adverse events, CV events and MACE (in CV-compromised patients), demographic data, baseline characteristics, medical history, prior use of medications for chronic medical conditions, concomitant medications used for at least 12 months prior to cohort entry, preventative migraine medications, pregnancy status, CV disease, hypertension, and other chronic medical conditions. Exposure to fremanezumab or other preventive migraine medications, medical history (including medicinal products prescribed), comorbidities, primary and secondary outcomes, potential confounding factors, and potential effect modifiers will be documented by the treating physicians.