Influence of exocrine pancreatic insufficiency on the formation of uremic toxin indoxyl sulfate in patients in a dialysis program

Study identification

• EU PAS number:
  EUPAS38785
• Study ID:
  38786
• Official title and acronym:
  Influence of exocrine pancreatic insufficiency on the formation of uremic toxin indoxyl sulfate in patients in a dialysis program
• DARWIN EU® study:
  No
• Study countries:
  Czechia
• Study description:
  A monocentric, prospective, open cohort study was performed. The study group consisted of 27 anuric patients from a single hemodialysis center undergoing chronic renal replacement therapy. The aim was to test anuric patients by using a non-invasive breath test with 13C mixed triglyceride for subclinical pancreatic insufficiency. We corellated these results with the serum concentrations of indoxyl sulfate in the patients. The elimination of indoxyl sulfate by current dialysis strategies are very difficult and only partial, it is necessary to consider the possibility of influencing the formation of indoxyl sulfate in vivo by reducting the residual protein entering the colon.
• Study status:
  Planned

Research institutions and networks

Institutions

University Hospital Hradec Králové

Study timelines

Date when funding contract was signed

Planned: 07/01/2019

Study start date

Planned: 01/02/2019

Date of final study report

Planned: 31/07/2021

Sources of funding

Other

More details on funding

Internal grant of University Hospital Hradec Kralove-Program to support applied health research

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable