Vitamin A supplementation in children hospitalized for measles in a high-income country

Study identification

• EU PAS number:
  EUPAS31805
• Study ID:
  32394
• Official title and acronym:
  Vitamin A supplementation in children hospitalized for measles in a high-income country
• DARWIN EU® study:
  No
• Study countries:
  Italy
• Study description:
  Worldwide medical authorities recommend vitamin A supplementation for severe measles infection requiring hospitalization. However, evidence supporting its use in high-income countries is lacking. A nationwide vitamin A shortage reported in concomitance with recent measles outbreak in Italy, provided the opportunity to test the efficacy of vitamin A in a high-income setting simulating a random allocation to the treatment.We conducted a prospective controlled cohort study involving children admitted to a tertiary-care hospital in Southern Italy (November 2015 - May 2019). The primary outcome was the duration of fever. Secondary outcomes included the length of hospitalization, the rate of complication, the need of antibiotic treatment and the body temperature.
• Study status:
  Planned

Research institutions and networks

Institutions

University of Naples Federico II

Department of Translational Medical Science – Section of Paediatrics

Study timelines

Date when funding contract was signed

Planned: 01/11/2015

Study start date

Planned: 01/11/2015

Date of final study report

Planned: 31/05/2019

Sources of funding

Other

More details on funding

University

Regulatory

• Was the study required by a regulatory body?:
  No
• Is the study required by a Risk Management Plan (RMP)?:
  Not applicable