Rationale and Background: To increase readiness of European data sources to conduct multi-site vaccine coverage, benefit and risk studiesResearch Question and Objective:The primary objective is to determine exposure in the population, and coverage of routine vaccinations in children and elderly. The secondary objective is to coverage estimates with external benchmarksStudy Design: The main study design is a retrospective dynamic cohort studyPopulation: The source population comprises of all subjects registered with one of the ADVANCE participating databases, which can link vaccination and population data and have provided their willingness to participate. The study population comprises all persons who are registered during the study period that starts January 1, 2000 and ends December 31, 2018. Outcome Parameters: Vaccine exposure and vaccine coverage Data Sources:Electronic health care databases (vaccine registries, record linkage, surveillance and GP based databases) currently available in the ADVANCE consortium and eligible are located in Denmark, Spain, Italy, UK and NetherlandsInformative data sourcesVaccine schedules: European Centre for Disease Prevention and Control (ECDC) vaccine schedules in Europe and national statistics on vaccination coverageBenchmark data: WHO estimates for following vaccines/doses in a country: BCG, DTP1, DTP3,HepB_BD, HepB3, Hib3, IPV1, MCV1, MCV2, PCV3, Pol3, RCV1, Rota, http://apps.who.int/immunization_monitoring/globalsummary/timeseries/tswucoveragedtp3.htmlPublished literature for HPV (Bruni, Lancet Global Health) and influenza (VENICE)