Spanish DILI Registry

We co-ordinate a collaborative network of specialists in liver and digestive diseases,internal medicine and clinical pharmacology from more than 50 Spanish hospitals. Our main objective is to prospectively identify liver diseases related to drugs or toxins,in a standardized manner,in both inpatients and outpatients attending the participating Units. In addition we aim to identify/evaluate the existence of risk factors that affect the susceptibility to drug-induced liver injury (DILI). We maintain a data base with information on demographics,temporal relationship between start of treatment and onset of liver disease,course of dechallenge,concomitant treatments,discarded alternative causes,laboratory findings,hypersensitivity features,autoimmunity,outcome,rechallenge and liver biopsy findings when available for each patient. In short our research areas include 1) clinical epidemiology,2) causality evaluation studies and 3) potential biomarkers for idiosyncratic DILI.