Centre de Pharmacovigilance (CRPV Lyon), ACRPV/ENTIS

Our department is located in a University Hospital (Hospices Civils de Lyon,HCL) and belongs to the network ACRPV. It includes a poison control,a pharmacovigilance and an addictovigilance center with a specialization for risk evaluation of drugs in pregnancy/lactation. We are member of ENTIS and participated in various committees and working groups of the French ANSM. We have developed a database (Terappel) dedicated to drugs in pregnancy with the aim to prospectively collect data on the outcome of pregnancy after drug exposure. Terappel is used by 18 French PV centers and contained more than 40,000 requests (83,000 drug exposures) and prospective data on the outcome of pregnancy for more than 20,000 patients that are used for collaborative national or international studies. We also have full access on data of patients hospitalized in HCL (14 hospitals,> 1.3 million days of hospitalisation) with a common electronic medical record and computerized prescriptions.